sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish
نویسندگان
چکیده
منابع مشابه
Ectopic Sox3 activity elicits sensory placode formation
The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that medaka Sox3 is expressed in the neuroectoderm and in the placodes of all sensory organs prior to placode formation and subsequently in placode-derived tissues. Ectopic Sox3 expression leads to ectopic expression of Pax6 and Eya1 in embryonic ectoderm and causes ectopic le...
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Development of neural and sensory primordia at the early stages of embryogenesis depends on the activity of two B1 Sox transcription factors, Sox2 and Sox3. The embryonic expression patterns of the Sox2 and Sox3 genes are similar, yet they show gene-unique features. We screened for enhancers of the 231-kb genomic region encompassing Sox3 of chicken, and identified 13 new enhancers that showed a...
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The vertebrate inner ear develops from initially 'simple' ectodermal placode and vesicle stages into the complex three-dimensional structure which is necessary for the senses of hearing and equilibrium. Although the main morphological events in vertebrate inner ear development are known, the genetic mechanisms controlling them are scarcely understood. Previous studies have suggested that the ot...
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Copper is an essential cellular cofactor that becomes toxic at high levels. Copper homeostasis is tightly regulated by opposing mechanisms that control copper import, export, and copper binding capacity within the cell. High levels of copper induce the expression of metallothioneins, small sulfhydryl-rich proteins with high metal binding capabilities that serve as neutralizers of toxic levels o...
متن کاملSprouty gene function in otic placode induction
other ions transepithelially with a suite of pumps and transporters, how these proton-secreting cells (PSCs) arise developmentally is unknown. Here, we identify a cell type in the X. laevis larval that expresses a collection of transporters strikingly similar to those observed in the mammalian kidney, including “kidney”-specific isoforms of the H+V-ATPase and Cl−/HCO3− antiporters related to pe...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2018
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2018.01.011